A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal

Background: Microglia have recently been implicated in opioid dependence and withdrawal. Mu opioid receptors are expressed in microglia, and microglia form intimate connections with nearby neurons. Accordingly, opioids have both direct (mu opioid receptor mediated) and indirect (neuron interaction m...

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Bibliographic Details
Main Authors: Kevin R. Coffey, Atom J. Lesiak, Russell G. Marx, Emily K. Vo, Gwenn A. Garden, John F. Neumaier
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Biological Psychiatry Global Open Science
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174321000884