RNAseq Analysis of FABP4 Knockout Mouse Hippocampal Transcriptome Suggests a Role for WNT/β-Catenin in Preventing Obesity-Induced Cognitive Impairment

RNAseq Analysis of FABP4 Knockout Mouse Hippocampal Transcriptome Suggests a Role for WNT/β-Catenin in Preventing Obesity-Induced Cognitive Impairment

Microglial fatty-acid binding protein 4 (FABP4) is a regulator of neuroinflammation. We hypothesized that the link between lipid metabolism and inflammation indicates a role for FABP4 in regulating high fat diet (HFD)-induced cognitive decline. We have previously shown that obese FABP4 knockout mice...

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Bibliographic Details
Main Authors: Simon W. So, Joshua P. Nixon, David A. Bernlohr, Tammy A. Butterick
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
obesity
transcriptome
hippocampus
long-term potentiation
cognitive decline
inflammation
Online Access:https://www.mdpi.com/1422-0067/24/4/3381

Internet

https://www.mdpi.com/1422-0067/24/4/3381

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