Osteocytic Pericellular Matrix (PCM): Accelerated Degradation under In Vivo Loading and Unloading Conditions Using a Novel Imaging Approach

Osteocytic Pericellular Matrix (PCM): Accelerated Degradation under In Vivo Loading and Unloading Conditions Using a Novel Imaging Approach

The proteoglycan-containing pericellular matrix (PCM) controls both the biophysical and biochemical microenvironment of osteocytes, which are the most abundant cells embedded and dispersed in bones. As a molecular sieve, osteocytic PCMs not only regulate mass transport to and from osteocytes but als...

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Bibliographic Details
Main Authors: Shaopeng Pei, Shubo Wang, Jerahme R. Martinez, Ashutosh Parajuli, Catherine B. Kirn-Safran, Mary C. Farach-Carson, X. Lucas Lu, Liyun Wang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Genes
Subjects:
osteocyte
click-chemistry
metabolic labeling
tibia loading
hindlimb suspension
pulse-chase experiment
Online Access:https://www.mdpi.com/2073-4425/13/1/72

Internet

https://www.mdpi.com/2073-4425/13/1/72

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