IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

Abstract Neuroinflammation contributes to secondary injury cascades following traumatic brain injury (TBI), with alternating waves of inflammation and resolution. Interleukin-1 (IL-1), a critical neuroinflammatory mediator originating from brain endothelial cells, microglia, astrocytes, and peripher...

Full description

Bibliographic Details
Main Authors: Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan, Adam D. Bachstetter
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Interleukin-1
Interleukin-1 receptor-1
Astrocyte
Microglia
Traumatic brain injury
Online Access:https://doi.org/10.1186/s12974-023-02934-3

Internet

https://doi.org/10.1186/s12974-023-02934-3

Similar Items