Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis

Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis

Heterozygous mutations in SNRPB, an essential core component of the five small ribonucleoprotein particles of the spliceosome, are responsible for cerebrocostomandibular syndrome (CCMS). We show that Snrpb heterozygous mouse embryos arrest shortly after implantation. Additionally, heterozygous delet...

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Bibliographic Details
Main Authors: Sabrina Shameen Alam, Shruti Kumar, Marie-Claude Beauchamp, Eric Bareke, Alexia Boucher, Nadine Nzirorera, Yanchen Dong, Reinnier Padilla, Si Jing Zhang, Jacek Majewski, Loydie A. Jerome-Majewska
Format: Article
Language:English
Published: The Company of Biologists 2022-06-01
Series:Disease Models & Mechanisms
Subjects:
cerebrocostomandibular syndrome
snrpb
splicing
neural crest cells
craniofacial
Online Access:http://dmm.biologists.org/content/15/6/dmm049544

Internet

http://dmm.biologists.org/content/15/6/dmm049544

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