Asymmetric Henry Reaction of Nitromethane with Substituted Aldehydes Catalyzed by Novel In Situ Generated Chiral Bis(β-Amino Alcohol-Cu(OAc)<sub>2</sub>·H<sub>2</sub>O Complex
Novel chiral thiophene-2,5-bis(β-amino alcohol) ligands (<b>L1</b>–<b>L5</b>) were designed and synthesized from thiophene-2,5-dicarbaldehyde (<b>3</b>) with chiral β-amino alcohols (<b>4a–e</b>) in 4 steps with overall 23% yields. An in situ generated...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
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| Series: | Catalysts |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4344/11/10/1208 |