HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAF<sup>V600E</sup> Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia

HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAF<sup>V600E</sup> Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia

Induction of heme oxygenase 1 (HO-1) favors immune-escape in BRAF<sup>V600</sup> melanoma cells treated with Vemurafenib/PLX4032 under standard cell culture conditions. However, the oxygen tension under standard culture conditions (~18 kPa O<sub>2</sub>) is significantly high...

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Bibliographic Details
Main Authors: Anna Lisa Furfaro, Giulia Loi, Caterina Ivaldo, Mario Passalacqua, Gabriella Pietra, Giovanni Enrico Mann, Mariapaola Nitti
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
HO-1
NK ligands
melanoma
oxygen tension
NRF2
physiological normoxia
Online Access:https://www.mdpi.com/2076-3921/11/6/1171

Internet

https://www.mdpi.com/2076-3921/11/6/1171

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