Connecting high-resolution 3D chromatin organization with epigenomics

While large-scale 3D genome architecture is well studied, the limits of resolution have hindered our understanding on the fine scale. Here the authors mapped 1D epigenomic profiles to fine-scale 3D chromatin structures with their deep learning model CAESAR. The model predicted fine-scale structures,...

Full description

Bibliographic Details
Main Authors: Fan Feng, Yuan Yao, Xue Qing David Wang, Xiaotian Zhang, Jie Liu
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29695-6