Generation and validation of small ADAMTS13 fragments for epitope mapping of anti‐ADAMTS13 autoantibodies in immune‐mediated thrombotic thrombocytopenic purpura

Generation and validation of small ADAMTS13 fragments for epitope mapping of anti‐ADAMTS13 autoantibodies in immune‐mediated thrombotic thrombocytopenic purpura

Abstract Background In immune‐mediated thrombotic thrombocytopenic purpura (iTTP), patients develop an immune response against the multidomain enzyme ADAMTS13. ADAMTS13 consists of a metalloprotease (M) and disintegrin‐like (D) domain, 8 thrombospondin type 1 repeats (T1‐T8), a cysteine‐rich (C), a...

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Bibliographic Details
Main Authors: Kadri Kangro, Elien Roose, An‐Sofie Schelpe, Edwige Tellier, Gilles Kaplanski, Jan Voorberg, Simon F. De Meyer, Andres Männik, Karen Vanhoorelbeke
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
ADAMTS13 protein
antibodies
epitopes
human serum albumin
thrombotic thrombocytopenic purpura
Online Access:https://doi.org/10.1002/rth2.12379

Internet

https://doi.org/10.1002/rth2.12379

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