Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells

Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells

Abstract Background Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phosphatase activity. TRAP 5a can be post-translationally processed to a cl...

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Bibliographic Details
Main Authors: Anja Reithmeier, Maria Norgård, Barbro Ek-Rylander, Tuomas Näreoja, Göran Andersson
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Molecular and Cell Biology
Subjects:
Cathepsin K
Tartrate-resistant acid phosphatase
ACP5
Proteolytic processing
Intracellular trafficking
Cancer
Online Access:http://link.springer.com/article/10.1186/s12860-020-00253-6

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http://link.springer.com/article/10.1186/s12860-020-00253-6

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