Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles

Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles

Recent studies have suggested that CD8+ liver-resident memory T (TRM) cells are crucial in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) to induce liver TRM cells in a murine model. Single-dose intravenous injections of ovalbumin m...

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Bibliographic Details
Main Authors: Sayuri Nakamae, Satoshi Miyagawa, Koki Ogawa, Mariko Kamiya, Mayumi Taniguchi, Akari Ono, Maho Kawaguchi, Awet Alem Teklemichael, Jiun-Yu Jian, Tamasa Araki, Yukimi Katagami, Hidefumi Mukai, Takeshi Annoura, Katsuyuki Yui, Kenji Hirayama, Shigeru Kawakami, Shusaku Mizukami
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
liver-stage malaria
vaccine
mRNA
lipid nanoparticles
resident memory T cells
cellular immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116299/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116299/full

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