A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer

A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer

PARP1 plays a critical role in regulating many biological processes linked to cellular stress responses. Although DNA strand breaks are potent stimuli of PARP1 enzymatic activity, the context-dependent mechanism regulating PARP1 activation and signaling is poorly understood. We performed global char...

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Bibliographic Details
Main Authors: Yuanli Zhen, Yajie Zhang, Yonghao Yu
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
proteomics
ADP-ribosylation
PARP
breast cancer
post-translational modification
DNA damage
transcription
mRNA metabolism
protein translation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315863

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http://www.sciencedirect.com/science/article/pii/S2211124717315863

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