Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening

<i>O</i>-GlcNAcylation is an essential post-translational modification installed by the enzyme <i>O</i>-β-<i>N</i>-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serio...

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Bibliographic Details
Main Authors: Elena M. Loi, Tihomir Tomašič, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, Marko Anderluh
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/27/6/1996