Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease
Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the combination of gray-matter (GM) atrophy and SV2A...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | NeuroImage |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921005255 |
| _version_ | 1819085263881633792 |
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| author | Yihuan Lu Takuya Toyonaga Mika Naganawa Jean-Dominique Gallezot Ming-Kai Chen Adam P. Mecca Christopher H. van Dyck Richard E. Carson |
| author_facet | Yihuan Lu Takuya Toyonaga Mika Naganawa Jean-Dominique Gallezot Ming-Kai Chen Adam P. Mecca Christopher H. van Dyck Richard E. Carson |
| author_sort | Yihuan Lu |
| collection | DOAJ |
| description | Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the combination of gray-matter (GM) atrophy and SV2A decrease in the remaining tissue. Our aim is to reveal the true SV2A change by performing partial volume correction (PVC). Methods: We performed two PVC algorithms, Müller-Gärtner (MG) and ‘iterative Yang’ (IY), on 17 AD participants and 11 cognitive normal (CN) participants using the brain-dedicated HRRT scanner. Distribution volume VT, the rate constant K1, binding potential BPND (centrum semiovale as reference region), and tissue volume were compared. Results: In most regions, both PVC algorithms reduced the between-group differences. Alternatively, in hippocampus, IY increased the significance of between-group differences while MG reduced it (VT, BPND and K1 group differences: uncorrected: 20%, 27%, 17%; MG: 18%, 22%, 14%; IY: 22%, 28%, 17%). The group difference in hippocampal volume (10%) was substantially smaller than any PET measures. MG increased GM binding values to a greater extent than IY due to differences in algorithm assumptions. Conclusion: 11C-UCB-J binding is significantly reduced in AD hippocampus, but PVC is important to adjust for significant volume reduction. After correction, PET measures are substantially more sensitive to group differences than volumetric MRI measures. Assumptions of each PVC algorithm are important and should be carefully examined and validated. For 11C-UCB-J, the less stringent assumptions of IY support its use as a PVC algorithm over MG. |
| first_indexed | 2024-12-21T21:01:35Z |
| format | Article |
| id | doaj.art-1b130473ba4e412bbffdd545c6e6b04d |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-21T21:01:35Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-1b130473ba4e412bbffdd545c6e6b04d2022-12-21T18:50:25ZengElsevierNeuroImage1095-95722021-09-01238118248Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's diseaseYihuan Lu0Takuya Toyonaga1Mika Naganawa2Jean-Dominique Gallezot3Ming-Kai Chen4Adam P. Mecca5Christopher H. van Dyck6Richard E. Carson7Department of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States; Corresponding author.Department of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United StatesDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United StatesDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United StatesDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United StatesDepartment of Psychiatry, Yale University, New Haven, CT, United StatesDepartment of Psychiatry, Yale University, New Haven, CT, United StatesDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United StatesPurpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the combination of gray-matter (GM) atrophy and SV2A decrease in the remaining tissue. Our aim is to reveal the true SV2A change by performing partial volume correction (PVC). Methods: We performed two PVC algorithms, Müller-Gärtner (MG) and ‘iterative Yang’ (IY), on 17 AD participants and 11 cognitive normal (CN) participants using the brain-dedicated HRRT scanner. Distribution volume VT, the rate constant K1, binding potential BPND (centrum semiovale as reference region), and tissue volume were compared. Results: In most regions, both PVC algorithms reduced the between-group differences. Alternatively, in hippocampus, IY increased the significance of between-group differences while MG reduced it (VT, BPND and K1 group differences: uncorrected: 20%, 27%, 17%; MG: 18%, 22%, 14%; IY: 22%, 28%, 17%). The group difference in hippocampal volume (10%) was substantially smaller than any PET measures. MG increased GM binding values to a greater extent than IY due to differences in algorithm assumptions. Conclusion: 11C-UCB-J binding is significantly reduced in AD hippocampus, but PVC is important to adjust for significant volume reduction. After correction, PET measures are substantially more sensitive to group differences than volumetric MRI measures. Assumptions of each PVC algorithm are important and should be carefully examined and validated. For 11C-UCB-J, the less stringent assumptions of IY support its use as a PVC algorithm over MG.http://www.sciencedirect.com/science/article/pii/S1053811921005255 |
| spellingShingle | Yihuan Lu Takuya Toyonaga Mika Naganawa Jean-Dominique Gallezot Ming-Kai Chen Adam P. Mecca Christopher H. van Dyck Richard E. Carson Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease NeuroImage |
| title | Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease |
| title_full | Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease |
| title_fullStr | Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease |
| title_full_unstemmed | Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease |
| title_short | Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease |
| title_sort | partial volume correction analysis for 11c ucb j pet studies of alzheimer s disease |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921005255 |
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