Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations

Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations

Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of Salmonella species strains including S. enteritidis, S. typhi, S. typhimurium, S. paratyphi, and S. abor...

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Bibliographic Details
Main Authors: Yonghui Wang, Meihui Hou, Zhaodong Kan, Guanghui Zhang, Yunxia Li, Lei Zhou, Changfa Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
type III secretion system inhibitor
virtual screening
molecular docking
Salmonella species
anti-bacterial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.764191/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.764191/full

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