Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts

Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts

BackgroundWe investigated whether p42/p44 extracellular signal-regulated kinases (ERK1/2) and/or phosphatidylinositol-3-OH kinase (PI3K)-Akt play a crucial role in cardioprotection by κ-opioid receptor (KOP) activation.MethodsLangendorff perfused rat hearts were subjected to 30 min of regional ische...

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Bibliographic Details
Main Authors: June Hong Kim, Young Ho Jang, Kook Jin Chun, Jun Kim, Yong Hyun Park, Jeong Su Kim, Jin Mo Kim, Mi Young Lee
Format: Article
Language:English
Published: Korean Society of Anesthesiologists 2011-05-01
Series:Korean Journal of Anesthesiology
Subjects:
coronary occlusion
heart
myocardial function
opioid receptors
reperfusion
Online Access:http://ekja.org/upload/pdf/kjae-60-351.pdf

Internet

http://ekja.org/upload/pdf/kjae-60-351.pdf

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