Limitations of Semi-Automated Immunomagnetic Separation of HLA-G-Positive Trophoblasts from Papanicolaou Smears for Prenatal Genetic Diagnostics

Limitations of Semi-Automated Immunomagnetic Separation of HLA-G-Positive Trophoblasts from Papanicolaou Smears for Prenatal Genetic Diagnostics

<b>Background:</b> In prenatal genetic diagnostics, the detection of single-gene defects relies on chorionic villus sampling (CVS) and amniocentesis, which carry a miscarriage risk of 0.2–0.3%. To mitigate this risk, fetal trophoblasts have been isolated from a Papanicolaou smear using T...

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Bibliographic Details
Main Authors: Eddy N. de Boer, Nicole Corsten-Janssen, Elles Wierenga, Theo Bijma, Jurjen T. Knapper, Gerard J. te Meerman, Gwendolyn T. R. Manten, Nine V. A. M. Knoers, Katelijne Bouman, Leonie K. Duin, Cleo C. van Diemen
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Diagnostics
Subjects:
prenatal genetic diagnostics
single-gene defects
fetal trophoblasts
Papanicolaou smear
semi-automated immunomagnetic cell sorting
Online Access:https://www.mdpi.com/2075-4418/15/3/386

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https://www.mdpi.com/2075-4418/15/3/386

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