Diverse MR1-restricted T cells in mice and humans

Diverse MR1-restricted T cells in mice and humans

Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human periph...

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Bibliographic Details
Main Authors: Hui-Fern Koay, Nicholas A. Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P. Fairlie, James McCluskey, Daniel G. Pellicci, Adam P. Uldrich, Dale I. Godfrey
Format: Article
Language:English
Published: Nature Portfolio 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10198-w

Internet

https://doi.org/10.1038/s41467-019-10198-w

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