Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice

Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice

Colorectal cancer (CRC) is a common disease and has limited treatment options. The importance of cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) in CRC has been increasingly recognized. However, the role of CAF subsets in CRC is hardly understood and opposing functions o...

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Bibliographic Details
Main Authors: Christina Heichler, Anabel Schmied, Karin Enderle, Kristina Scheibe, Marta Murawska, Benjamin Schmid, Maximilian J. Waldner, Markus F. Neurath, Clemens Neufert
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
fibroblast
collagen
colorectal cancer
tumorigenesis
AOM/DSS model
inflammation
Online Access:https://www.mdpi.com/2072-6694/14/6/1472

Internet

https://www.mdpi.com/2072-6694/14/6/1472

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