Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model

Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model

BackgroundMajor depressive disorder (MDD) refers to a mental disease with complex pathogenesis and treatment mechanism. S-ketamine exhibited high effectiveness in treating MDD. However, the pharmacological activity of S-ketamine has not been reported yet.Materials and MethodsIn this study, depressio...

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Bibliographic Details
Main Authors: Lanwei Hou, Jingyu Miao, Haiwei Meng, Xiao Liu, Di Wang, Yawen Tan, Chuangang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Psychiatry
Subjects:
depression
S-ketamine
SIRT1
BDNF
synaptic ultrastructure
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.855810/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.855810/full

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