Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss
Otosyphilis is one contributing cause of hearing loss in adult patients. There are limited studies on the treatment regimens of otosyphilis. Penicillin G sodium (PGS) plus additional medications, such as benzathine penicillin and probenecid, is an effective regimen. This study investigated the effic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/2/47 |
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| author | Verajit Chotmongkol Sittichai Khamsai Patravoot Vatanasapt Kittisak Sawanyawisuth |
| author_facet | Verajit Chotmongkol Sittichai Khamsai Patravoot Vatanasapt Kittisak Sawanyawisuth |
| author_sort | Verajit Chotmongkol |
| collection | DOAJ |
| description | Otosyphilis is one contributing cause of hearing loss in adult patients. There are limited studies on the treatment regimens of otosyphilis. Penicillin G sodium (PGS) plus additional medications, such as benzathine penicillin and probenecid, is an effective regimen. This study investigated the efficacy of PGS alone for the treatment of otosyphilis. We conducted a retrospective study and included all consecutive patients diagnosed with otosyphilis who received only PGS treatment. The study period was from 2009 to 2013. The PGS treatment regimen was PGS 4 mu intravenously every four hours (24 mu/day) for 14 days. Clinical and audiogram outcomes were evaluated one year after treatment. There were 34 otosyphilis patients that were treated with PGS. After one year of treatment, 18 patients (52.9%) had a clinical improvement and 11 patients (32.4%) had an audiogram improvement. In conclusion, PGS at 24 mu/day for two weeks provided an audiogram improvement one year after treatment in one-third of the patients. |
| first_indexed | 2024-12-14T00:05:19Z |
| format | Article |
| id | doaj.art-1b1f08025e9249488a4f04458e2a5006 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-14T00:05:19Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1b1f08025e9249488a4f04458e2a50062022-12-21T23:26:04ZengMDPI AGAntibiotics2079-63822019-04-01824710.3390/antibiotics8020047antibiotics8020047Penicillin G Sodium as a Treatment of Otosyphilis with Hearing LossVerajit Chotmongkol0Sittichai Khamsai1Patravoot Vatanasapt2Kittisak Sawanyawisuth3Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandOtosyphilis is one contributing cause of hearing loss in adult patients. There are limited studies on the treatment regimens of otosyphilis. Penicillin G sodium (PGS) plus additional medications, such as benzathine penicillin and probenecid, is an effective regimen. This study investigated the efficacy of PGS alone for the treatment of otosyphilis. We conducted a retrospective study and included all consecutive patients diagnosed with otosyphilis who received only PGS treatment. The study period was from 2009 to 2013. The PGS treatment regimen was PGS 4 mu intravenously every four hours (24 mu/day) for 14 days. Clinical and audiogram outcomes were evaluated one year after treatment. There were 34 otosyphilis patients that were treated with PGS. After one year of treatment, 18 patients (52.9%) had a clinical improvement and 11 patients (32.4%) had an audiogram improvement. In conclusion, PGS at 24 mu/day for two weeks provided an audiogram improvement one year after treatment in one-third of the patients.https://www.mdpi.com/2079-6382/8/2/47otosyphilis<i>Treponema pallidum</i>treatmentpenicillinoutcomesaudiogram |
| spellingShingle | Verajit Chotmongkol Sittichai Khamsai Patravoot Vatanasapt Kittisak Sawanyawisuth Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss Antibiotics otosyphilis <i>Treponema pallidum</i> treatment penicillin outcomes audiogram |
| title | Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss |
| title_full | Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss |
| title_fullStr | Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss |
| title_full_unstemmed | Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss |
| title_short | Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss |
| title_sort | penicillin g sodium as a treatment of otosyphilis with hearing loss |
| topic | otosyphilis <i>Treponema pallidum</i> treatment penicillin outcomes audiogram |
| url | https://www.mdpi.com/2079-6382/8/2/47 |
| work_keys_str_mv | AT verajitchotmongkol penicillingsodiumasatreatmentofotosyphiliswithhearingloss AT sittichaikhamsai penicillingsodiumasatreatmentofotosyphiliswithhearingloss AT patravootvatanasapt penicillingsodiumasatreatmentofotosyphiliswithhearingloss AT kittisaksawanyawisuth penicillingsodiumasatreatmentofotosyphiliswithhearingloss |