A simple, nonenzymatic method for desialylating polysialylated ganglio-N-tetraose series gangliosides to produce GM1

Dowex-50W-H+ was used to catalyze the highly selective desialylation of polysialylated ganglio-N-tetraose series gangliosides to yield primarily GM1. High performance thin-layer chromatographic analysis of recovered lipid indicated that 60–70% of the recovered ganglioside was GM1. Identification of...

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Bibliographic Details
Main Authors: Cara-Lynne Schengrund, Pavol Kováč
Format: Article
Language:English
Published: Elsevier 1999-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520333514