BNTA alleviates inflammatory osteolysis by the SOD mediated anti-oxidation and anti-inflammation effect on inhibiting osteoclastogenesis

BNTA alleviates inflammatory osteolysis by the SOD mediated anti-oxidation and anti-inflammation effect on inhibiting osteoclastogenesis

Abnormal activation and overproliferation of osteoclast in inflammatory bone diseases lead to osteolysis and bone mass loss. Although current pharmacological treatments have made extensive advances, limitations still exist. N-[2-bromo-4-(phenylsulfonyl)-3-thienyl]-2-chlorobenzamide (BNTA) is an arti...

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Bibliographic Details
Main Authors: Huidong Wang, Xiankun Cao, Jiadong Guo, Xiao Yang, Xiaojiang Sun, Zhiyi Fu, An Qin, Yujie Wu, Jie Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
BNTA
MAPK
SOD
osteolysis
inflammatory osteolysis
bone loss
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.939929/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.939929/full

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