Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.
Bruton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec kinases are allosterically activated by the a...
| Những tác giả chính: | , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
| Được phát hành: |
Public Library of Science (PLoS)
2016-03-01
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| Loạt: | PLoS Computational Biology |
| Truy cập trực tuyến: | http://europepmc.org/articles/PMC4807093?pdf=render |