Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza

Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza

BackgroundInfluenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening and fatal complication of severe influenza infection.MethodsWe measured RNA expression of 469 biologically plausible candidate genes...

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Main Authors: Tanya Novak, Jeremy Chase Crawford, Georg Hahn, Mark W. Hall, Simone A. Thair, Margaret M. Newhams, Janet Chou, Peter M. Mourani, Keiko M. Tarquinio, Barry Markovitz, Laura L. Loftis, Scott L. Weiss, Renee Higgerson, Adam J. Schwarz, Neethi P. Pinto, Neal J. Thomas, Rainer G. Gedeit, Ronald C. Sanders, Sidharth Mahapatra, Bria M. Coates, Natalie Z. Cvijanovich, Kate G. Ackerman, David W. Tellez, Patrick McQuillen, Stephen C. Kurachek, Steven L. Shein, Christoph Lange, Paul G. Thomas, Adrienne G. Randolph
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
influenza
sepsis
organ failure
pediatric intensive care
neutrophil degranulation
MODS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1220028/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1220028/full

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