Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate

Liquid-liquid phase separation (LLPS) is reported to occur in the intracellular environment. Here the authors show that heparan sulphate serves as a platform for basic fibroblast growth factor to undergo LLPS on the cell surface, therefore facilitating downstream signalling

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Song Xue, Fan Zhou, Tian Zhao, Huimin Zhao, Xuewei Wang, Long Chen, Jin-ping Li, Shi-Zhong Luo
التنسيق: مقال
اللغة:English
منشور في: Nature Portfolio 2022-03-01
سلاسل:Nature Communications
الوصول للمادة أونلاين:https://doi.org/10.1038/s41467-022-28765-z