Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression

Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression

The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular matrix (ECM) is significantly altered in desmoplasia, and as such plays a critical role in driving cancer progression. Us...

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Bibliographic Details
Main Authors: Maria Rafaeva, Adina R. D. Jensen, Edward R. Horton, Kamilla W. Zornhagen, Jan E. Strøbech, Lutz Fleischhauer, Alejandro E. Mayorca-Guiliani, Sebastian R. Nielsen, Dina S. Grønseth, Filip Kuś, Erwin M. Schoof, Luis Arnes, Manuel Koch, Hauke Clausen-Schaumann, Valerio Izzi, Raphael Reuten, Janine T. Erler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
extracellular matrix
fibroblasts
mechanics
models
desmoplasia
pancreatic cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154528/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154528/full

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