Transcription Factor Binding Affinities and DNA Shape Readout

Summary: An essential event in gene regulation is the binding of a transcription factor (TF) to its target DNA. Models considering the interactions between the TF and the DNA geometry proved to be successful approaches to describe this binding event, while conserving data interpretability. However,...

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Bibliographic Details
Main Authors: Max Schnepf, Marc von Reutern, Claudia Ludwig, Christophe Jung, Ulrike Gaul
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308865