Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation

Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation

Abstract Background Gouty arthritis is the most frequently diagnosed inflammatory arthritis worldwide. Dynamin-related protein 1 (Drp1), a regulator of mitochondrial fission, contributes to various inflammatory disorders via activating NLRP3 inflammasome. However, the biological role of Drp1 in gout...

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Bibliographic Details
Main Authors: Qingdong Wang, Hongbin Qiu
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Arthritis Research & Therapy
Subjects:
USP16
Drp1
Mitochondrial fission
NF-κB
NLRP3
Gouty arthritis
Online Access:https://doi.org/10.1186/s13075-023-03095-7

Internet

https://doi.org/10.1186/s13075-023-03095-7

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