Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation
Abstract Background Gouty arthritis is the most frequently diagnosed inflammatory arthritis worldwide. Dynamin-related protein 1 (Drp1), a regulator of mitochondrial fission, contributes to various inflammatory disorders via activating NLRP3 inflammasome. However, the biological role of Drp1 in gout...
| Główni autorzy: | , |
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| Format: | Artykuł |
| Język: | English |
| Wydane: |
BMC
2023-07-01
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| Seria: | Arthritis Research & Therapy |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1186/s13075-023-03095-7 |