Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation
Abstract Background Gouty arthritis is the most frequently diagnosed inflammatory arthritis worldwide. Dynamin-related protein 1 (Drp1), a regulator of mitochondrial fission, contributes to various inflammatory disorders via activating NLRP3 inflammasome. However, the biological role of Drp1 in gout...
| المؤلفون الرئيسيون: | , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
BMC
2023-07-01
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| سلاسل: | Arthritis Research & Therapy |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1186/s13075-023-03095-7 |