Stage-specific activity of potential antimalarial compounds measured in vitro by flow cytometry in comparison to optical microscopy and hypoxanthine uptake

The evaluation of new antimalarial agents using older methods of monitoring sensitivity to antimalarial drugs are laborious and poorly suited to discriminate stage-specific activity. We used flow cytometry to study the effect of established antimalarial compounds, cysteine protease inhibitors, and a...

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Bibliographic Details
Main Authors: Carmen E Contreras, María A Rivas, José Domínguez, Jaime Charris, Mario Palacios, Nicolás E Bianco, Isaac Blanca
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2004-03-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200011