CRISPR interference for sequence-specific regulation of fibroblast growth factor receptor A in Schistosoma mansoni

CRISPR interference for sequence-specific regulation of fibroblast growth factor receptor A in Schistosoma mansoni

Employing the flatworm parasite Schistosoma mansoni as a model, we report the first application of CRISPR interference (CRISPRi) in parasitic helminths for loss-of-function studies targeting the SmfgfrA gene which encodes the stem cell marker, fibroblast growth factor receptor A (FGFRA). SmFGFRA is...

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Bibliographic Details
Main Authors: Xiaofeng Du, Donald P. McManus, Juliet D. French, Natasha Collinson, Haran Sivakumaran, Skye R. MacGregor, Conor E. Fogarty, Malcolm K. Jones, Hong You
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
Schistosoma mansoni
CRISPR interference
fibroblast growth factor receptor A
stem cells
transcription regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1105719/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1105719/full

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