EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, chronic granulomatous disease, but its mechanism of action was unknown until...

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Bibliographic Details
Main Authors: Lyra O Randzavola, Paige M Mortimer, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C Williamson, Shreehari Suresh, John M Sowerby, Misaki Matsumoto, Celio XC Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, William M Rae, Gordon J Dougan, John Grainger, Paul J Lehner, Michael A Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth GC Smith, Francesca Magnani, David C Thomas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
NADPH oxidase;
chaperone;
inflammasome
P2X receptor
OST complex
T cells
Online Access:https://elifesciences.org/articles/76387

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https://elifesciences.org/articles/76387

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