NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW)
Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are difficult to reach, high solubility and thermal stabil...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-02-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/643 |
| _version_ | 1797874939738456064 |
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| author | A. V. Shatalova A. S. Yakubova V. V. Palimpsestov I. B. Esmagambetov |
| author_facet | A. V. Shatalova A. S. Yakubova V. V. Palimpsestov I. B. Esmagambetov |
| author_sort | A. V. Shatalova |
| collection | DOAJ |
| description | Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are difficult to reach, high solubility and thermal stability, etc. Nanobodies can be easily manufactured in microorganisms (E. coli) to significantly save on cost.Text. Goal of the paper consists of the description of structural and functional properties of nanobodies and its effective application.Conclusion. Nanobodies can be used in many fields of medicine and biotechnology such as research, diagnostics and therapy of oncology, infectious, hematological, inflammatory, autoimmune and neurological diseases. They can also be easily modified using another nanobody, molecules or radioactive mark as necessary. Nanobodies have huge potential for applications in diagnostics, therapy and medicine. |
| first_indexed | 2024-04-10T01:39:51Z |
| format | Article |
| id | doaj.art-1b48fd5e5bdb4b40be92c3e827b14a76 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:39:51Z |
| publishDate | 2019-02-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-1b48fd5e5bdb4b40be92c3e827b14a762023-03-13T09:14:00ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-02-0181142210.33380/2305-2066-2019-8-1-14-22643NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW)A. V. Shatalova0A. S. Yakubova1V. V. Palimpsestov2I. B. Esmagambetov3ФГАОУ ВО «Российский университет дружбы народов» (РУДН)ФГАОУ ВО «Российский университет дружбы народов» (РУДН)ФГБОУ ВО «Московский педагогический государственный университет»ФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н. Ф. Гамалеи» Министерства здравоохранения Российской ФедерацииIntroduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are difficult to reach, high solubility and thermal stability, etc. Nanobodies can be easily manufactured in microorganisms (E. coli) to significantly save on cost.Text. Goal of the paper consists of the description of structural and functional properties of nanobodies and its effective application.Conclusion. Nanobodies can be used in many fields of medicine and biotechnology such as research, diagnostics and therapy of oncology, infectious, hematological, inflammatory, autoimmune and neurological diseases. They can also be easily modified using another nanobody, molecules or radioactive mark as necessary. Nanobodies have huge potential for applications in diagnostics, therapy and medicine.https://www.pharmjournal.ru/jour/article/view/643наноантителаоднодоменные антителаvhh |
| spellingShingle | A. V. Shatalova A. S. Yakubova V. V. Palimpsestov I. B. Esmagambetov NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) Разработка и регистрация лекарственных средств наноантитела однодоменные антитела vhh |
| title | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_full | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_fullStr | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_full_unstemmed | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_short | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_sort | nanobodies structure manufacturing application review |
| topic | наноантитела однодоменные антитела vhh |
| url | https://www.pharmjournal.ru/jour/article/view/643 |
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