High glucose-induced glucagon resistance and membrane distribution of GCGR revealed by super-resolution imaging

Summary: The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Many research works have been carried out on GCGR structure, glucagon signaling pathway, and GCGR antagonists. However, the expression and fine distribution of GCGR proteins in response to glucagon un...

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Bibliographic Details
Main Authors: Jing Gao, Hongru Li, Haijiao Xu, Yong Liu, Mingjun Cai, Yan Shi, Jingrui Zhang, Hongda Wang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000445