Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6

Abstract Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these are encoded by sequences within the mitochondrial 12S and 16S ribosomal genes: humanin, MOTS-c, and the six SHLP peptides, SHLP1-SHLP6. These peptides have vario...

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Bibliographic Details
Main Authors: James M. Gruschus, Daniel L. Morris, Nico Tjandra
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41053-0