Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

To combat emerging infectious diseases like Zika virus (ZIKV), synthetic messenger RNAs (mRNAs) encoding viral antigens are very attractive as they allow a rapid, generic, and flexible production of vaccines. In this work, we engineered a self-replicating mRNA (sr-mRNA) vaccine encoding the pre-memb...

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Bibliographic Details
Main Authors: Zifu Zhong, João Paulo Portela Catani, Séan Mc Cafferty, Liesbeth Couck, Wim Van Den Broeck, Nina Gorlé, Roosmarijn E. Vandenbroucke, Bert Devriendt, Sebastian Ulbert, Lieselotte Cnops, Johan Michels, Kevin K. Ariën, Niek N. Sanders
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Vaccines
Subjects:
self-replicating mRNA
Zika virus vaccine
type I interferon response
IFNAR1 knockout mice
Online Access:https://www.mdpi.com/2076-393X/7/3/96

Internet

https://www.mdpi.com/2076-393X/7/3/96

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