VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model

VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model

Abstract Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a recent phase II trial with a PACAP-inhibiting antibody s...

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Bibliographic Details
Main Authors: Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen
Format: Article
Language:English
Published: BMC 2024-07-01
Series:The Journal of Headache and Pain
Subjects:
PACAP
VPAC1
VPAC2
PAC1
Migraine
von Frey
Online Access:https://doi.org/10.1186/s10194-024-01830-2

Internet

https://doi.org/10.1186/s10194-024-01830-2

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