Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase

Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase

Eukaryotic Elongation Factor-2 Kinase (eEF2K) acts as a negative regulator of protein synthesis, translation, and cell growth. As a structurally unique member of the alpha-kinase family, eEF2K is essential to cell survival under stressful conditions, as it contributes to both cell viability and prol...

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Bibliographic Details
Main Authors: Darby J. Ballard, Hao-Yun Peng, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
cancer
drug development
mTORC1
AMPK
eEF2K
immunometabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.727863/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.727863/full

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