CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Tumor–stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated fibroblasts (CAFs) and mast cells (MC) affected the sensitivity of PDAC cells to gemcitabine/nabpaclitaxel (GEM/NAB). For this purpo...

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Bibliographic Details
Main Authors: Letizia Porcelli, Rosa Maria Iacobazzi, Roberta Di Fonte, Simona Serratì, Angelica Intini, Antonio Giovanni Solimando, Oronzo Brunetti, Angela Calabrese, Francesco Leonetti, Amalia Azzariti, Nicola Silvestris
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
CAFs
gemcitabine
mast cells
nabpaclitaxel
pancreatic cancer
Online Access:http://www.mdpi.com/2072-6694/11/3/330

Internet

http://www.mdpi.com/2072-6694/11/3/330

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