Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

Abstract Background Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory disea...

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Bibliographic Details
Main Authors: Piao Luo, Qian Zhang, Tian-Yu Zhong, Jia-Yun Chen, Jun-Zhe Zhang, Ya Tian, Liu-Hai Zheng, Fan Yang, Ling-Yun Dai, Chang Zou, Zhi-Jie Li, Jing-Hua Liu, Ji-Gang Wang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Military Medical Research
Subjects:
Celastrol
Sepsis
Pyruvate kinase M2
High mobility group box 1
Aerobic glycolysis
Online Access:https://doi.org/10.1186/s40779-022-00381-4

Internet

https://doi.org/10.1186/s40779-022-00381-4

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