Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages

Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages

Abstract Background Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppression through multiple cell intrinsic mechanisms. However, release of extracellular vesicles (EVs) has the potential to transmit molecular cargos between cells. I...

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Bibliographic Details
Main Authors: Stoyan Tankov, Marija Petrovic, Marc Lecoultre, Felipe Espinoza, Nadia El-Harane, Viviane Bes, Sylvie Chliate, Darel Martinez Bedoya, Olivier Jordan, Gerrit Borchard, Denis Migliorini, Valérie Dutoit, Paul R. Walker
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Subjects:
cGAS-STING pathway
Extracellular vesicles
Glioblastoma
Hypoxia/ miRNA
Online Access:https://doi.org/10.1186/s12964-024-01523-y

Internet

https://doi.org/10.1186/s12964-024-01523-y

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