Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons

Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons

Kaurenoic acid (KA) is a diterpene extracted from <i>Sphagneticola trilobata</i> (L.) Pruski. KA presents analgesic properties. However, the analgesic activity and mechanisms of action of KA in neuropathic pain have not been investigated so far; thus, we addressed these points in the pre...

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Bibliographic Details
Main Authors: Tiago H. Zaninelli, Sandra S. Mizokami, Mariana M. Bertozzi, Telma Saraiva-Santos, Felipe A. Pinho-Ribeiro, Gabriele Inácio de Oliveira, Renata Streck, Eduardo J. A. Araújo, Nilton S. Arakawa, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
neuropathic pain
chronic constriction injury
CCI
nitric oxide
analgesia
<i>Sphagneticola trilobata</i>
Online Access:https://www.mdpi.com/1424-8247/16/3/343

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https://www.mdpi.com/1424-8247/16/3/343

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