Variants of CARD8 in Leishmania guyanensis-cutaneous leishmaniasis and influence of the variants genotypes on circulating plasma cytokines IL-1β, TNFα and IL-8.

Variants of CARD8 in Leishmania guyanensis-cutaneous leishmaniasis and influence of the variants genotypes on circulating plasma cytokines IL-1β, TNFα and IL-8.

Nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein family (NLR) are intracellular pathogen recognition receptors mediating innate immunity, releasing proinflammatory cytokines IL-1β and IL-18, and promoting pyroptotic cell death, upon sensing pathogenic or endogenous d...

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Bibliographic Details
Main Authors: Héctor David Graterol Sequera, Josué Lacerda de Souza, José do Espírito Santo Junior, Lener Santos da Silva, Suzana Kanawati Pinheiro, Herllon Karllos Athaydes Kerr, Mara Lúcia Gomes de Souza, Marcus Vinitius de Farias Guerra, Tirza Gabrielle Ramos de Mesquita, Rajendranath Ramasawmy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0011416

Internet

https://doi.org/10.1371/journal.pntd.0011416

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