Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice

Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice

Abstract Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is presented where glycolysis is inhibited in cancer cells using PFK15 (inhibitor of PFKFB3, rate-limiting st...

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Bibliographic Details
Main Authors: Sahil Inamdar, Abhirami P. Suresh, Joslyn L. Mangal, Nathan D. Ng, Alison Sundem, Christopher Wu, Kelly Lintecum, Abhirami Thumsi, Taravat Khodaei, Michelle Halim, Nicole Appel, Madhan Mohan Chandra Sekhar Jaggarapu, Arezoo Esrafili, Jordan R. Yaron, Marion Curtis, Abhinav P. Acharya
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41016-z

Internet

https://doi.org/10.1038/s41467-023-41016-z

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