A library of cancer testis specific T cell receptors for T cell receptor gene therapy

A library of cancer testis specific T cell receptors for T cell receptor gene therapy

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To increase the number of cancer patients that can be treated with T cell receptor (TCR) gene therapy, we aimed to identify a set of high-affinity cancer-specific TCRs targeting different melanoma-associated antigens (MAGEs). In this study, peptides derived from MAGE genes with tumor-specific expres...

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Bibliographic Details
Main Authors: Marije A.J. de Rooij, Dennis F.G. Remst, Dirk M. van der Steen, Anne K. Wouters, Renate S. Hagedoorn, Michel G.D. Kester, Miranda H. Meeuwsen, Tassilo L.A. Wachsmann, Arnoud H. de Ru, Peter A. van Veelen, Els M.E. Verdegaal, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
T cell receptor
MAGE
CD8+ T cells
Cancer Testis genes
TCR gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001425

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http://www.sciencedirect.com/science/article/pii/S2372770522001425

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