Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy

Abstract In this study we performed a step-wise optimization of biologically active IL-2 for delivery using E. coli Nissle 1917. Engineering of the strain was coupled with an in vitro cell assay to measure the biological activity of microbially produced IL-2 (mi-IL2). Next, we assessed the immune mo...

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Bibliographic Details
Main Authors: Sarunas Tumas, Trine Sundebo Meldgaard, Troels Holger Vaaben, Sara Suarez Hernandez, Annemette Tengstedt Rasmussen, Ruben Vazquez-Uribe, Sine Reker Hadrup, Morten O. A. Sommer
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39365-2

Internet

https://doi.org/10.1038/s41598-023-39365-2

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