Uncovering the Mechanism of Azepino‐Indole Skeleton Formation via Pictet–Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation

Uncovering the Mechanism of Azepino‐Indole Skeleton Formation via Pictet–Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation

Abstract Strictosidine synthase (STR) catalyzes the Pictet–Spengler (PS) reaction of tryptamine and secologanin to produce strictosidine. Recent studies demonstrated that the enzyme can also catalyze the reaction of non‐natural substrates to form new alkaloid skeletons. For example, the PS condensat...

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Bibliographic Details
Main Authors: Mingqi Mou, Dr. Chenghua Zhang, Dr. Shiqing Zhang, Fuqiang Chen, Dr. Hao Su, Prof. Dr. Xiang Sheng
Format: Article
Language:English
Published: Wiley-VCH 2023-06-01
Series:ChemistryOpen
Subjects:
reaction mechanisms
density functional theory calculations
Pictet−Spengler reaction
quantum chemistry
strictosidine synthase
Online Access:https://doi.org/10.1002/open.202300043

Internet

https://doi.org/10.1002/open.202300043

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