Uncovering the Mechanism of Azepino‐Indole Skeleton Formation via Pictet–Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation

Uncovering the Mechanism of Azepino‐Indole Skeleton Formation via Pictet–Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation

Abstract Strictosidine synthase (STR) catalyzes the Pictet–Spengler (PS) reaction of tryptamine and secologanin to produce strictosidine. Recent studies demonstrated that the enzyme can also catalyze the reaction of non‐natural substrates to form new alkaloid skeletons. For example, the PS condensat...

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Bibliográfalaš dieđut
Váldodahkkit: Mingqi Mou, Dr. Chenghua Zhang, Dr. Shiqing Zhang, Fuqiang Chen, Dr. Hao Su, Prof. Dr. Xiang Sheng
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Wiley-VCH 2023-06-01
Ráidu:ChemistryOpen
Fáttát:
reaction mechanisms
density functional theory calculations
Pictet−Spengler reaction
quantum chemistry
strictosidine synthase
Liŋkkat:https://doi.org/10.1002/open.202300043

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https://doi.org/10.1002/open.202300043

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